CELL CITY · B01 · KNOW YOUR CELL CITY

Name: _______________________ Class: __________ Date: __________

Discover the jobs · 1 of 2

Match four jobs in the orientation. Identify their landmarks, then explain each contribution to this protein-export route.

B01.1 · Nucleus / City Hall

What does the nucleus contribute to this protein-export system? Distinguish instructions from protein cargo.

B01.2 · Ribosomes + rough ER / Protein Works

Which structure makes this protein, and how does the rough ER help prepare it?

B01.3 · Golgi apparatus / Shipping Center

How does the Golgi contribute a different job from the ribosomes and rough ER?

B01.4 · Cell membrane / Export Dock

How does the protein leave through the cell membrane? What happens to the vesicle membrane?

Trace the cooperation

Sketch and label the protein-export route. Show the instruction step separately. These four structures are part of an animal cell, not a complete cell.

CELL CITY · B01 · KNOW YOUR CELL CITY

Name: _______________________ Class: __________ Date: __________

Explain the cooperation · 2 of 2

B01.5 · Claim

How can these structures work together to export a protein?

B01.5 · Evidence

Name two structures you identified and describe their different jobs in the model.

B01.5 · Reasoning and prediction

Connect those jobs to successful export. Predict what would happen if the Golgi stopped working.

B01.6 · Model limitation

Our map uses designated locations and paved roads. Explain one difference from a real cell and how it limits this model.

After your A01 delivery

Describe one handoff you observed. Did it support your explanation? Add a revision if needed.

Submit both B01 pages with A01 if assigned. Matching and driving do not grade reasoning. Your teacher reviews your evidence and explanations.

CELL CITY COURIER · ANIMAL CELL CAMPAIGN · A01 · PAGE 1 OF 2

Special delivery: observations

Name: __________________________ Class: __________ Date: __________

Play → observe → write. Use biological names. The game pauses at each handoff.

A01.1 · Dispatch / Nucleus

What stays in the nucleus? What carries a copy of its instructions outward?

A01.2 · Protein Works / Ribosomes + Rough ER

Which structure makes the protein? How does the rough ER help? What do the sealed pod and its motor vehicle represent?

A01.3 · Shipping Center / Golgi apparatus

How is the Golgi’s job different from the ribosome’s job? What leaves the Golgi?

A01.4 · Export Dock / Cell membrane

Name the export process. What happens to the vesicle membrane and protein cargo?

A01.5 · Predict a failure

Predict what happens to this protein’s export if the Golgi stops processing and sorting. Explain using the Golgi’s role.

Sketch your delivery model

Label the protein route, the structures involved, and where the protein leaves the cell.

CELL CITY COURIER · ANIMAL CELL CAMPAIGN · A01.6 · PAGE 2 OF 2

Final CER: city versus cell

Name: __________________________ Class: __________ Date: __________

Question: How well does Cell City represent how a real cell makes and exports a protein?

Your answer should explain what the model represents well and one way it differs from a real cell.

C · Claim

Answer the question in one sentence. State how useful or accurate the game is as a model.

Starter: “Cell City is a ___ model of protein export because ___.”

E · Evidence

Describe two specific examples you saw or did in the mission. Name the city features and the real cell structures they represent. Use your page 1 observations.

Starters: “First, I observed ___.” “Second, I observed ___.”

R · Reasoning, including a model limitation

Explain how your examples support your claim, using what you know about cell structures working together. Then describe one difference between the game and a real cell, and explain what the real cell is actually like.

Starters: “These examples support my claim because ___.” “One limitation is ___. In a real cell, ___.” Consider the roads, flat map, or fixed buildings.

MS-LS1-2: “Develop and use a model to describe the function of a cell as a whole and ways parts of cells contribute to the function.”
Your CER uses a model to explain how cell parts cooperate and identifies a limit of that model.

R01 · Microtubule Express

Name: ______________________ Class: ______ Date: __________

Mission: board at Platform A; observe the moving motor, pause ATP for two seconds, restore ATP, and deliver the vesicle to Platform B.

Record observations

With ATP available: ____________________________________________

When ATP was paused: ________________________________________

When ATP returned: ___________________________________________

What evidence shows that this cargo transport requires cellular energy?

Claim

Answer the question directly.

Evidence

Use your ATP-off and ATP-on observations.

Reasoning

Connect ATP use, the motor, and cargo movement. Explain one difference between the train model and a real cell.

Speed does not determine whether transport is active. This is motor-driven movement inside a cell, not membrane pumping. MS-LS1-2: Develop and use a model to describe the function of a cell as a whole and ways parts of cells contribute to the function.

T01 · The Last Block

Name: __________________ Class: ______ Date: __________

Collect the Golgi cargo, drive a Kinesin Courier to the Handoff Yard, switch to a Myosin Scooter, and deliver along the violet actin path.

Observations

When I switched motors, what changed? What stayed the same?

How did the transport system work together to deliver your cargo?

C · Claim

State how the parts cooperated.

E · Evidence

Describe two specific mission observations; name the cell parts.

R · Reasoning

Explain how those observations support your claim.

Model limitation

The courier walked between vehicles. Does a real cell contain a human driver? Explain how that differs from molecular transport. Walking is not diffusion.

MS-LS1-2: Develop and use a model to describe the function of a cell as a whole and ways parts of cells contribute to the function.
This model shows cooperation among cell parts; motor details are enrichment.

Q01 · Keep the Cell Working

Name: __________________ Class: ______ Date: __________

Call chaperone repair. Enter the faulty demonstration motor. Let CHIP tag it, then transfer your healthy pod to a working transport. Visit Protein Recycling and the lysosome.

Observe

When you switched vehicles, what kept the tag? What happened to the healthy cargo?

How does repairing or removing damaged components help the cell continue functioning?

C · Claim

E · Evidence

Describe two mission observations and identify the cell parts.

R · Reasoning

Connect the evidence to continued cell function.

Model limitation

Do real quality-control enzymes detect speeding or intentions? Explain what they recognize instead.

MS-LS1-2: Develop and use a model to describe the function of a cell as a whole and ways parts of cells contribute to the function.
The model connects maintenance of cell parts to whole-cell function. Molecular details are enrichment.